位置:首页 > 产品库 > Rapanone
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Rapanone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rapanone图片
CAS NO:573-40-0
包装与价格:
包装价格(元)
10 mg询价
1 mL*10 mM(in DMSO)询价

2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone
2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione
酸藤子醌
拉帕酮
Rapanone 是一种具有广泛生物活性的天然苯醌,如抗肿瘤、抗氧化、抗炎、抗菌和抗寄生虫活性。它还是选择性人滑膜PLA2抑制剂,IC50值为 2.6 μM。

产品描述

Rapanone is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.

体外活性

In the HepG2, rapanone (20–40 μM) induced a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization.Rapanone impairs mitochondrial respiration by inhibiting electron transport chain at Complex III and promotes mitochondrial dysfunction[1].

体内活性

In mice,rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model

Cas No.

573-40-0

分子式

C19H30O4

分子量

322.44

别名

2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone;2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione;酸藤子醌;拉帕酮

储存和溶解度

DMSO:65 mg/ml (201.59 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024