2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone
2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione
酸藤子醌
拉帕酮
Rapanone 是一种具有广泛生物活性的天然苯醌,如抗肿瘤、抗氧化、抗炎、抗菌和抗寄生虫活性。它还是选择性人滑膜PLA2抑制剂,IC50值为 2.6 μM。
产品描述
Rapanone is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.
体外活性
In the HepG2, rapanone (20–40 μM) induced a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization.Rapanone impairs mitochondrial respiration by inhibiting electron transport chain at Complex III and promotes mitochondrial dysfunction[1].
体内活性
In mice,rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model
Cas No.
573-40-0
分子式
C19H30O4
分子量
322.44
别名
2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone;2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione;酸藤子醌;拉帕酮
储存和溶解度
DMSO:65 mg/ml (201.59 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years