Phyllanthin 是 Phyllanthus amarus 的一种主要生物活性木脂素成分，具有显著的抗氧化和保肝活性。

Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp.

The activity of P-gp and MRP2 was determined in the uptake assays by monitoring the intracellular accumulation of their specific substrates (calcein acetoxymethyl ester and 5(6)-carboxy-2',7'-dichlorofluorescein diacetate, respectively) with fluorescence spectroscopy. HypoPhyllanthin and Phyllanthin inhibited P-gp function with comparable potencies, but neither compound affected MRP2 activity. When the lignans were washed out before addition of substrate, the inhibitory action of both compounds against P-gp function was lost. These results suggested the reversibility of the inhibition. Moreover, prolonged exposure of the Caco-2 cells to both lignans (up to 7 days) had no effect on P-gp function[1]

10351-88-9

C24H34O6

418.52

1,1'-[(2S,3S)-2,3-双(甲氧基甲基)-1,4-丁二基]双[3,4-二甲氧基苯];叶下珠素

DMSO:55 mg/ml (131.42 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years