BergaPTEN 是白芷中的一种香豆素，也是一种补骨脂素，可抑制细胞复制。

Bergapten, a psoralen, inhibits cell replication.

在对乙酰氨基酚（APAP）诱导的C57BL / 6J小鼠中,Bergapten能够发挥抗氧化活性,改善肝毒性.

在乳腺癌他莫昔芬敏感和耐药细胞中,Bergapten能够消除ERα,重新调整靶向ERα的膜信号,促进细胞有丝分裂的潜力。

5-Methoxypsoralen (5-MOP) is dissolved in DMSO and stored, and then diluted with appropriate medium (final DMSO<0.1%) before use[1]. The human colon adenocarcinoma cell line (COLO 205, from a 70-year-old male Caucasian) sre placed into 75-cm2 tissue culture flasks and grown in RPMI1640 medium, supplemented with 10% fetal bovine serum, containing penicillin and streptomycin (100 Ig/mL) and 1 mM glutamine, at 37°C in a humidified atmosphere of 5% CO2 and 95% O2. The human stomach adenocarcinoma cell line are placed into 75-cm2 tissue culture flasks and grown in RPMI 1640 medium, supplemented with 10% fetal bovine serum, containing penicillin and streptomycin (100 Ig/mL) and 1 mM glutamine, at 37°C in a humidified atmosphere of 5% CO2 and 95% O2. SC-M1 and COLO 205 cells are treated with different concentrations of 5-MOP (0.05, 0.5, 5, 10, 25 and 50 mM) and incubated for 72 h for the dose-effect study of 5-MOP on NAT activity. To determine the time-course effect of 0.5 mM 5-MOP on NAT activity, the cells are incubated at 37AC and harvested at 12, 24, 48 and 72 h, respectively. 5-MOP is dissolved in DMSO and the final concentration of vehicle is<0.1%. Only DMSO (solvent) is added for the control regimen[1].

484-20-8

C12H8O4

216.19

佛手柑内酯;5-Methoxypsoralen;香柑内酯

H2O:<1 mgml
DMSO:5 mg/mL (23.12 mM)
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years