PF-5190457 是具有选择性的、有效的生长素释放肽受体选择性的反向激动剂(pKi:8.36)。
产品描述
PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).
体外活性
PF-5190457 has a superior balance of ghrelin receptor pharmacology. It also has off-target selectivity [1].
体内活性
In human whole and dispersed islets, PF-5190457 has excellent selectivity and demonstrates robust increases in glucose-stimulated insulin secretion[1].
Cas No.
1334782-79-4
分子式
C29H32N6OS
分子量
512.67
别名
PF-05190457
储存和溶解度
DMSO:250 mg/mL (487.64 mM),Need ultrasonic
Ethanol:100 mg/mL (195.06 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
