PU 23 是一种多药抗性蛋白4(MRP4)的抑制剂。
产品描述
PU 23 is an inhibitor of multidrug-resistant protein 4 (MRP4).
体外活性
6-Mercaptopurine (6-MP) inhibits HEK293 and HEK293/MRP4 cells with IC50s of 2.81 and 14.11 μM, respectively. The combination of PU23 and 6-MP inhibits HEK293 and HEK293/MRP4 cells with IC50s of 1.84 and 6.06 μM, respectively.Preincubation of HEK293/MRP4 cells with PU 23 (50 μM) for 2 h also significantly increases the amount of 6-MP in cells [1].
Cas No.
817635-93-1
分子式
C21H19N3O3S2
分子量
425.52
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
