Indican 是吲哚酚的一种糖苷，染料靛蓝和靛玉红的前体。它的主要代谢物是硫酸吲哚酚 (IS)。其中IS 是尿毒症毒素，是有机阴离子转运蛋白1 (OAT 1)、OAT 3 和多药耐药相关蛋白4 (MRP 4) 的底物/抑制剂。
产品描述
Indican is a natural protective compound that is used to protect the liver.
体外活性
Oral single doses of Indican at 20, 40 mg/kg increase the systemic exposure of MTX and MRT by inhibiting multiple anion transporters including OAT 1, OAT 3, and MRP 4 via the major metabolite indoxyl sulfate (IS) [3].
Cas No.
487-60-5
分子式
C14H17NO6
分子量
295.29
别名
NSC-87517;Indoxyl-β-D-glucoside;NSC87517;3-Indoxyl-beta-D-glucopyranoside;NSC 87517;3-吲哚基-beta-D-吡喃葡萄糖苷
储存和溶解度
DMSO:88 mg/mL (298.01 mM)
H2O:8 mg/mL (27.09 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
