ON 146040 是一种有效的 PI3K 异构体抑制剂，对 PI3Kα 和 PI3Kδ 的 IC50 分别为 14 和 20 nM。
产品描述
ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.
体外活性
ON 146040 inhibits Abl1 and several mutant versions of this kinase with IC50< 150 nM. ON 146040 is highly potent in killing hematologic tumor cells with IC50 values in the 150 to 1000 nM range. ON 146040 downregulates the phosphorylation of STAT3 and STAT5 in leukemia and myeloma cells[1].
Cas No.
1404231-34-0
分子式
C24H23N7O3S
分子量
489.55
别名
ZINC211117138
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
