Cyclic di-GMP 是一种 STING 激动剂和细菌第二信使，可协调细菌生长和行为的不同方面，包括运动性、毒力、生物膜形成和细胞周期进程。 Cyclic di-GMP 具有抗癌细胞增殖活性，还诱导 CD4 受体表达升高和细胞周期停滞。 Cyclic di-GMP 可用于癌症研究。
| Cas No. | 61093-23-0 |
| 别名 | 环二鸟苷酸,c-di-GMP; cyclic diguanylate; 5GP-5GP |
| 化学名 | 9,9'-((2R,3R,3aS,7aR,9R,10R,10aS,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidodecahydrodifuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl)bis(2-amino-1H-purin-6(9H)-one) |
| Canonical SMILES | O=C1NC(N)=NC2=C1N=CN2[C@H](O[C@@]([C@@]3([H])OP(O)(OC[C@]([C@@]4([H])OP5(O)=O)(O[C@@H](N6C(N=C(N)NC7=O)=C7N=C6)[C@@H]4O)[H])=O)(CO5)[H])[C@@H]3O |
| 分子式 | C20H24N10O14P2 |
| 分子量 | 690.41 |
| 溶解度 | Soluble in Water |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Cyclic-di-GMP is a STING agonist and a ubiquitous second messenger that regulates biofilm formation, motility, and virulence in diverse bacterial species. References:
[1]. Nakamura T, et al. Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J Control Release. 2015 Oct 28;216:149-57.
[2]. Burdette DL, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 2011 Sep 25;478(7370):515-8. |
