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HQL 79
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
HQL 79图片
CAS NO:162641-16-9
包装与价格：
包装价格(元)
10mg询价
50mg询价

HQL 79 是一种强效、选择性和口服活性的人类造血前列腺素 D 合酶 (H-PGDS) 抑制剂，高度选择性地抑制 PGD2 的合成，并作为抗过敏剂，Kd 为 0.8 μM，IC50 为 6微米。
Cas No.162641-16-9
别名4-(二苯基甲氧基)-1-[3-(2H-四氮唑-5-基)丙基]哌啶
化学名1-(3-(2H-tetrazol-5-yl)propyl)-4-(benzhydryloxy)piperidine
Canonical SMILESN1(CCCC2=NNN=N2)CCC(CC1)OC(C3=CC=CC=C3)C4=CC=CC=C4
分子式C22H27N5O
分子量377.48
溶解度Methanol: 2.5 mg/ml
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

HQL-79 is a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS[1].

HQL-79 is a competitive inhibitor against substrate PGH2 and a non-competitive one against GSH[1].

References:
[1]. Aritake K, et al. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2;281(22):15277-86. Epub 2006 Mar 17.

 
 
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