Ponatinib Hydrochloride 是 ponatinib 的盐酸盐。Ponatinib 是一种有效的，具有口服活性的多靶点激酶抑制剂，抑制 Abl，PDGFRα，VEGFR2，FGFR1 和 Src 的 IC50 分别为 0.37 nM、1.1 nM、1.5 nM、2.2 nM 和 5.4 nM。

Ponatinib Hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

1114544-31-8

C29H28ClF3N6O

569.02

AP-24534 Hydrochloride;AP24534 Hydrochloride

DMSO:22.5mg/mL (39.5mM),ultrasonic and warming and heat to 60°C)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years