TTBK1-IN-2 是 Tau-Tubulin 激酶 (TTBK1) 的抑制剂，IC50 为 0.24 和 4.22 μM。 TTBK1-IN-2 降低细胞培养物和转基因 TDP-43 小鼠脊髓中的 TDP-43 磷酸化。

TTBK1-IN-2 is an inhibitor of Tau-Tubulin kinase (TTBK1) with IC50s of 0.24 and 4.22 μM. TTBK1-IN-2 reduces TDP-43 phosphorylation both in cell cultures and the spinal cord of transgenic TDP-43 mice.

2765453-51-6

C18H13ClN4O

336.77

N-[4-(4-chlorophenoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

DMSO:45 mg/mL (133.62 mM),ultrasonic and adjust pH to 2 with HCl
Powder: -20°C for 3 years
In solvent: -80°C for 2 years