PRT 4165 是有效的PRC1介导 H2A 泛素化的抑制剂。
产品描述
PRT4165 is a potent PRC1-mediated H2A ubiquitylation inhibitor.
体外活性
Inhibit the?in vitro?E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex and H2A/H2AX ubiquitination
体内活性
Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination?in vitro?and?in vivo.
Cas No.
31083-55-3
分子式
C15H9NO2
分子量
235.24
别名
PRT 4165;NSC600157
储存和溶解度
DMSO:23.5 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
