6-Mercaptopurine hydrate 是一种核苷代谢抑制剂。它通过抑制嘌呤代谢来干扰核酸合成，通常与其他药物联合用于白血病的治疗或缓解维持计划。

6-Mercaptopurine anhydrous is a Nucleoside Metabolic Inhibitor. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.

Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. [1] Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA. Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis. [2]

6112-76-1

C5H6N4OS

170.19

6-巯基嘌呤(一水合物);6-Mercaptopurine monohydrate;6-巯基嘌呤 一水合物;6-Mercaptopurine (6-MP) Monohydrate

H2O:<1 mgml
DMSO:100 mg/mL
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years