L189 是一种人类 DNA 连接酶抑制剂，抑制 hLigI/III/IV，IC50值分别为5、9 和 5 μM。
产品描述
L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).
体外活性
L189 inhibits DNA ligases I, III and IV in DNA joining assays with purified proteins and in cell extract assays of DNA replication, base excision repair and non-homologous end joinging. L189 markedly increases killing of HCT116 colon cancer cells and the other cancer cell lines by ionizing radiation.
Cas No.
64232-83-3
分子式
C11H10N4OS
分子量
246.29
储存和溶解度
H2O:Insoluble
DMSO:25 mg/mL
Ethanol:1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
