L755507 是一种有效的选择性β3-AR 激动剂，IC50值为 35 nM。
产品描述
L755507 is an effective, selective agonist of β3-AR（IC50=35 nM）.
体外活性
L-755,507 displays an excellent activity profile as an extremely potent human β3 adrenergic receptor agonist (β3 EC50 0.43 nM), with >440-fold selectivity over β1 and β2 binding[1]. L755507 causes a robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human β3-adrenoceptors(pEC50 values of 12.3)[4]. In a recent study employing a high-throughput screen to identify chemicals capable of modulating HR-mediated genome editing, L-755507 is identified that could enhance HR repair by up to ninefold[3].
体内活性
Acute exposure of rhesus monkeys to L-755,507 elicits lipolysis and metabolic rate elevation, and that chronic exposure increases uncoupling protein 1 expression in rhesus brown adipose tissue[2].
Cas No.
159182-43-1
分子式
C30H40N4O6S
分子量
584.73
储存和溶解度
DMSO:58.5 mg/mL (100 mM)
Ethanol:58.5 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
