Chloroquine 是一种自噬和 Toll 样受体抑制剂。 氯喹是一种抗疟疾和抗炎剂，广泛用于治疗疟疾和类风湿性关节炎。它在体外控制 SARS-CoV-2 (COVID-19) 感染方面非常有效，EC50 为 1.13 μM。

Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro with EC50 of 1.13 μM.

Chloroquine suppressed matrix metalloproteinase (MMP)-2 and MMP-9 mRNA expression and protein activity, whereas MMP-13 mRNA expression and proteolytic activity were increased.?Despite enhancing TLR9 mRNA expression, chloroquine suppressed TLR9 protein expression in vitro[1].

Daily treatment of mice with intraperitoneal (i.p.) chloroquine (80 mg/kg/day) for 22 days, did not inhibit the growth of control siRNA or TLR9 siRNA MDA-MB-231 breast cancer cells[1].

54-05-7

C18H26ClN3

319.87

DMSO:100 mg/mL (312.63 mM)
Ethanol:100 mg/mL (312.63 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years