Okanin 是鬼针草中的一种有效成分，可通过抑制TLR4/NF-κB信号通路减弱 LPS 诱导的小胶质细胞活化。

Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.

Activity-guided fractionation of the EtOH extract of flowers of Bidens bipinnata L. have been furnished five flavonoids, sulfuretin(1), butein(2), 7,8,3?2,4?2-tetrahydroxyflavanone(3), maritimetin(4) and Okanin(5). All of the compounds showed significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect. The evaluation for protective effect of isolated compounds against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells was conducted. Compounds 1, 3, 4 and 5 showed significant protective effects with the EC50 values of 36.1±0.9, 23.3±0.7, 41.0±1.0 and 29.8±1.1 μM, respectively[1]

484-76-4

C15H12O6

288.25

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years