Lusutrombopag 是一种口服生物可利用的小分子血小板生成素 (TPO) 受体激动剂，用于选择性侵入性手术前患有血小板减少症的慢性肝病的患者。
产品描述
Lusutrombopag is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist for chronic liver disease (CLD) patients with thrombocytopenia prior to elective invasive surgery.
体外活性
Lusutrombopag is an agonist of the thrombopoietin receptor that activates platelet production. Lusutrombopag acts selectively on the human TPO receptor and activates signal transduction pathways that promote the proliferation and differentiation of bone marrow cells into megakaryocytes, thereby increasing platelet levels.
Cas No.
1110766-97-6
分子式
C29H32Cl2N2O5S
分子量
591.55
别名
鲁索曲波帕;Mulpleta;S-888711;芦曲泊帕
储存和溶解度
DMSO:30 mg/mL (50.72 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
