Ac-YVAD-CMK是一种选择性的、不可逆的Caspase-1抑制剂，并能抑制焦亡作用、IL-1β和IL-18。Ac-YVAD-CMK显示出神经保护和抗炎的能力。
产品描述
Ac-YVAD-CMK is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.
体外活性
Ac-YVAD-cmk (40 and 80 μM) reduces the expression of IL-1β and IL-18 in activated microglia[3].
体内活性
In SD rats, Ac-YVAD-cmk treatment (1 μg; injection into the left lateral ventricle) significantly decreases the protein levels of caspase-1 and mature IL-1β/IL-18 compared with the ICH group[3]. Ac-YVAD-cmk (12.5 μmol/kg) significantly reduces mortality from 83 to 33% in rats[4].
Cas No.
178603-78-6
分子式
C24H33ClN4O8
分子量
540.99
别名
Ac-Tyr-Val-Ala-Asp-chloromethylketone;Caspase-1 Inhibitor II;Ac-Tyr-Val-Ala-Asp-CMK
储存和溶解度
DMSO:90 mg/mL (166.4 mM),Need ultrasonic
DMF:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
