Mequitazine 是一种有效的、非镇静剂和长效组胺 H1 拮抗剂。
产品描述
Mequitazine is an effective, nonsedative and long-acting histamine H1 antagonist.
体外活性
Mequitazine is widely studied and used for allergic disorders such as hay fever and urticaria[1]. Mequitazine demonstrates significant bactericidal effects against all the tested clinical isolates including Ps. aeruginosa. Its effect against the Gram-positive isolates is more pronounced [2].
体内活性
Mequitazine antagonizes the effect of histamine in guinea-pig ileum competitively. Mequitazine at 107 produces a parallel shift of the dose-response curve to acetylcholine in the rat duodenum. Mequitazine at highest concentration shows anticholinergic activity [3]. Mequitazine inhibits contractile responses to KCl, phenylephrine (PE), 5-hydroxytryptamine (5-HT), and Ca2+ in rat aorta [4].
Cas No.
29216-28-2
分子式
C20H22N2S
分子量
322.47
别名
Primalan;LM-209;美喹他嗪;Metaplexan;Virginan
储存和溶解度
DMSO:15 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
