群多普利 (RU44570) 是一种非巯基前药，可水解为活性二酸群多普利拉。
| Cas No. | 87679-37-6 |
| 别名 | 群多普利; RU44570 |
| 化学名 | (2S,3aR,7aS)-1-((S)-2-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)octahydro-1H-indole-2-carboxylic acid |
| Canonical SMILES | O=C([C@@H](N[C@H](C(OCC)=O)CCC1=CC=CC=C1)C)N2[C@H](C(O)=O)C[C@@]3([H])CCCC[C@@]32[H] |
| 分子式 | C24H34N2O5 |
| 分子量 | 430.54 |
| 溶解度 | DMF: 15 mg/ml,DMSO: 25 mg/ml,Ethanol: 0.25 mg/ml,PBS (pH 7.2): 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Trandolapril (RU44570) is a nonsulfhydryl prodrug that is hydrolysed to the active diacid Trandolaprilat. Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that has been used in the treatment of hypertension and congestive heart failure (CHF), and after myocardial infarction (MI)[1]. References:
[1]. Peters DC, et al. Trandolapril. An update of its pharmacology and therapeutic use in cardiovascular disorders. Drugs. 1998 Nov;56(5):871-93. |
