Complement C5-IN-1 (Compound 7) 是补体成分蛋白5 (C5) 的小分子抑制剂。 Complement C5-IN-1 与 C5 相互作用以防止其被 C5 转化酶切割, 阻断酵母多糖诱导的 50％人全血 MAC 沉积的 IC50 值为 0.77 μM。

Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5).

Complement C5-IN-1 (Compound 7) interacts with C5 to prevent its cleavage by the C5 convertase and blocks zymosan-induced the membrane-attack complex (MAC) deposition in 50% human whole blood (IC50: 0.77 μM)[1].

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C24H32N2O6

444.52

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