LY3295668 is an effective and orally active and highly specific inhibitor of Aurora-A kinase (Ki: 0.8 nM and 1038 nM for AurA and AurB, respectively).

LY3295668 is a highly specific AurA inhibitor, can kill Rb-deficient cancer cells at doses that have minimal effects on normal cells. Only 5 of 386 kinases are potently inhibited by LY3295668 (<10 nM), in a kinome-wide survey.

1919888-06-4

C24H26ClF2N5O2

489.95

AK-01

DMSO:150 mg/mL (306.15 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years