Sinensetin是从水果中发现的一种甲基化黄酮,有很强的抗血管和抗炎症的能力。
产品描述
Sinensetin is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.
体外活性
Sinensetin promots adipogenesis in 3T3-L1 preadipocytes growing in incomplete differentiation medium, sinensetin enhances adipogenesis and lipolysis by increasing cAMP levels. Sinensetin shows anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α).
体内活性
Sinensetin has the most potent antiangiogenesis activity and the lowest toxicity, inhibits angiogenesis by inducing cell cycle arrest in the G0/G1 phase in HUVEC culture and downregulating the mRNA expressions of angiogenesis genes flt1, kdrl, and hras in zebrafish.
Cas No.
2306-27-6
分子式
C20H20O7
分子量
372.373
别名
甜橙素;Pedalitin permethyl ether
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years