GB1107 是一种有效的选择性 Galectin-3 抑制剂，Kd 为 37 nM。

GB1107 is an effective and selective Galectin-3 inhibitor with a Kd of 37 nM.

GB1107 (0-1 μM) increases CD8+ T cell infiltration and tumor M1 macrophage polarization. GB1107 potentiates the effects of a PD-L1 immune checkpoint inhibitor to increase the expression of cytotoxic and apoptotic effector molecules including perforin-1, Fas ligand, IFN-γ, granzyme B, and cleaved caspase-3[1].

In CD-1 nude female mice received 3x106 human lung adenocarcinoma cells (A549), GB1107 (10 mg/kg, p.o.) significantly reduces tumor growth and final tumor weights[1].

1978336-61-6

C20H16Cl2F3N3O4S

522.33

DMSO:45 mg/mL (86.15 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years