SR-717 是非核苷类STING激动剂，是稳定的环鸟苷单磷酸腺苷单磷酸类似物，具有抗肿瘤活性，在 ISG-THP1 (WT) 和 ISG-THP1 cGAS KO (cGAS KO) 细胞中的EC50分别为 2.1 和 2.2 μM。

SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. Antitumor activity[1].

SR-717 displayed antitumor activity;?promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues;?and facilitated antigen cross-priming.?SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner.

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C15H8F2LiN5O3

351.2

DMSO:14.29 mg/mL (40.69 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years