Pleconaril 是一种有潜力研究肠病毒的衣壳抑制剂,， 它可有效抑制复制, IC50值为 50 nM。
产品描述
Pleconaril is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication (IC50: 50 nM).
体外活性
Pleconaril is a capsid inhibitor designed to dock within a hydrophobic pocket formed by the capsid proteins VP1, VP3 and VP2. Pleconaril leads to stiffening of the capsid structure, preventing RNA release into the cell.
Cas No.
153168-05-9
分子式
C18H18F3N3O3
分子量
381.355
别名
Picovir;普可那利;VP 63843;Win 63843
储存和溶解度
DMSO:10 mg/mL,warmed
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
