TPX-0005 是ROS1(IC50=0.07 nM) 和TRK(对 TRKA/B/C 的IC50=0.83/0.05/0.1 nM) 抑制剂，能够抑制 WTALK(IC50=1.01 nM)。它具有抗癌作用。

TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.

1802220-02-5

C18H18FN5O2

355.373

TPX 0005;TPX0005;TPX-0005

DMSO:83.3 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years