AZ1495 是一种口服有活性的白介素-1受体相关激酶 4(IRAK4)抑制剂，能够作用于 IRAK4 (IC50:5 nM)和 IRAK1 (IC50:23 nM)。可用于研究突变型 MyD88L265P弥漫性 B 细胞淋巴瘤 (DLBCL) 。
产品描述
AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Which Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL).
Cas No.
2196204-23-4
分子式
C21H31N5O2
分子量
385.5
储存和溶解度
DMSO:10 mg/mL (25.94 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
