TLR1 是细胞穿透Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop的小分子模拟物，能够阻碍 IL-1 受体介导的反应。

TLR1 is a cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic and inhibits IL-1 receptor-mediated responses.

In EL4 thymoma cells and in freshly isolated murine lymphocytes, TLR1 inhibits IL-1β-induced phosphorylation of the mitogen-activated protein kinase p38 in a concentration-dependent manner.

TLR1 produces a significant attenuation of the IL-1β-induced fever response (200 mg/kg, i.p.).

566914-00-9

C18H26N2O2

302.41

N-[(1S)-2-甲基-1-(1-吡咯烷羰基)丙基]-苯丙酰胺

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years