ML116 是一种有效的选择性 STAT3 抑制剂。
产品描述
ML116 is a potent and selective STAT3 inhibitor.
体外活性
Probe ML116 exhibits a STAT3 IC50 value of approximately 4 micromolar and does not inhibit the STAT1, STAT5, or NFkB signaling pathways (IC50 values greater than 56 micromolar), as determined using cell-based luciferase reporter assays.?Quantitative PCR experiments demonstrated that probe ML116 inhibits transcription of the STAT3-regulated gene BCL3
Cas No.
744270-00-6
分子式
C18H19N3S
分子量
309.43
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
