iCRT 14 是 β-连环蛋白应答转录抑制剂，能够抑制 Wnt 信号通路(IC50:40.3 nM)。
产品描述
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
体外活性
iCRT14 can interfere with TCF binding to DNA in addition to its ability to influence TCF-β-cat interaction. iCRT14 (10, 25, 50 μM) effectively inhibits cell proliferation in BT-549 cells in a dose- and time-dependent manner but is still less potent than iCRT3.
体内活性
CRT14 (50 mg/kg, i.p.) markedly decreases CycD1, proliferation of the tumors in HCT116 xenografts.
Cas No.
677331-12-3
分子式
C21H17N3O2S
分子量
375.45
储存和溶解度
DMSO:28 mg/mL (74.6 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
