BML-284 HCL 是细胞通透性 Wnt 信号激活剂。它能够诱导 TCF 依赖的转录活性(EC50>700 nM)。
产品描述
BML-284 HCL is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.
体外活性
BML-284 HCL does not inhibit the activity of GSK-3β, and may be a useful tool in the study of physiological processes that involve the Wnt pathway.
体内活性
In a Xenopus model, Wnt agonist 1 (10 μM) mimics the effects of Wnt at the whole-organism level, and affects Xenopus embryonic head specification.
Cas No.
2095432-75-8
分子式
C19H19ClN4O3
分子量
386.84
别名
Wnt agonist 1 HCL;BML-284 HCL
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
