Hexamethylene amiloride是 amiloride 的衍生物，也是 Na+/H+交换抑制剂，可降低白血病细胞的细胞内 pH (pHi) 并诱导凋亡。
产品描述
HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 μM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-2.4 μM for various NHE isoforms. HMA also blocks ASIC3 channels by 51% at 20 μM.
Cas No.
1428-95-1
分子式
C12H18ClN7O
分子量
311.77
别名
5-（N，N-六亚甲基）阿米洛利;HMA-5;5-HMA;Hexamethylene amiloride;5-(N,N-Hexamethylene)amiloride
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
