PhiKan 083 是咔唑衍生物，可以稳定p53的突变体Y220C，Kd值为 167 μM。它可用于癌症研究。
产品描述
PhiKan 083 is a carbazole derivative
体外活性
PhiKan 083 reduces the cell viability of engineered variants of Ln229 cells, in conbination with NSC 123127 (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells (p53wt, p53Y220C, p53G245S, p53R282W)[1].
Cas No.
880813-36-5
分子式
C16H18N2
分子量
238.33
储存和溶解度
Ethanol:100 mg/mL (419.59 mM),Need ultrasonic
DMSO:115 mg/mL (482.52 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
