ASTX660 是一种口服生物可利用的 cIAP 和 XIAP 双重拮抗剂。
产品描述
ASTX660 is an orally bioavailable dual antagonist of cIAP and XIAP.
体外活性
Twenty-one triple-negative breast cancer (TNBC) cell lines are treated with ASTX660 in vitro and it is found that 43% are sensitive to ASTX660.
体内活性
ASTX660 (daily oral treatment) inhibits tumor growth moderately but not a regression in HCC1806 xenografts in mice.
Cas No.
1799328-86-1
分子式
C30H42FN5O3
分子量
539.68
储存和溶解度
DMSO:47 mg/mL(87.09 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
