Phenoxodiol是合成genestein的类似物，激活线粒体Caspase系统，抑制XIAP，使癌细胞对fas介导的凋亡敏感。它在细胞周期的G1/S期诱导细胞周期阻滞，通过独立于p53的方式上调p21WAF1。它通过稳定可分裂复合物抑制DNA拓扑异构酶II，从而阻止DNA复制。

Phenoxodiol activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner. Phenoxodiol also inhibits DNA topoisomerase II.

Phenoxodiol, at concentrations >or=1 microg/ml (4 microM), inhibited proliferation and reduced the viability of healthy donor-derived PBMC. In contrast, lower Phenoxodiol concentrations (0.05-0.5 microg/ml) augmented, upon 3-day incubation, peripheral blood mononuclear cells cytotoxicity. Experiments with purified CD56(+) lymphocytes revealed that Phenoxodiol enhanced the lytic function of natural killer cells by directly stimulating this lymphocytic subpopulation[3].

Balb/C mice administered low-dose Phenoxodiol exhibited significantly reduced tumour growth rates and prolonged survival (in 40% of the animals) in a colon cancer model[3].

81267-65-4

C15H12O3

240.25

Haginin E;脱氢雌马酚;Dehydroequol;Idronoxil

DMSO:50 mg/mL (208.12 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years