VLX600 是一种铁螯合氧化磷酸化抑制剂，是一种细胞渗透性抗癌剂。它通过减少肿瘤细胞中的线粒体氧化磷酸化起作用。
产品描述
VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells.
体外活性
VLX600 as a drug that is preferentially active against quiescent cells in colon cancer 3-D microtissues.?The anticancer activity is associated with reduced mitochondrial respiration, leading to bioenergetic catastrophe and tumour cell death.?VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation.?Importantly, VLX600 displays tumour growth inhibition in vivo.
细胞实验
HCT116, HT29, SW620, HT8, DLD and RKO cells.Concentration,0.1, 1, 10, 100μM. 72 hours
Cas No.
327031-55-0
分子式
C17H15N7
分子量
317.356
储存和溶解度
DMSO:8 mg/ml(25.21 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
