Tropisetron 是一种 α7-烟碱受体激动剂和 5-HT3 受体拮抗剂，Ki值分别为 6.9 和 5.3 nM。
产品描述
Tropisetron is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.
体内活性
Tolbisetron induces anti-inflammatory effects in experimental models of cisplatin-induced nephrotoxicity that are completely independent of the 5-HT3 receptor. Tropisetron can improve ischemic brain injury by reducing TNF-α levels and myeloperoxidase activity[3].
Cas No.
89565-68-4
分子式
C17H20N2O2
分子量
284.35
别名
托烷司琼;ICS 205-930;Tropisetronum;Tropisteron
储存和溶解度
DMSO:8 mg/mL(28.13 mM)
H2O:50 mg/mL(175.84 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
