Dipraglurant (ADX48621) 是一种有效的、选择性的、具有口服活性和脑渗透性的 mGluR5 负变构调节剂 (NAM)，IC50 为 21 nM。
| Cas No. | 872363-17-2 |
| 别名 | 6-氟-2-[4-(吡啶-2-基)-3-丁炔基]咪唑并[1,2-A]吡啶,ADX 48621;ADX48621;ADX-48621 |
| 化学名 | 6-fluoro-2-(4-pyridin-2-ylbut-3-ynyl)imidazo[1,2-a]pyridine |
| Canonical SMILES | C1=CC=NC(=C1)C#CCCC2=CN3C=C(C=CC3=N2)F |
| 分子式 | C16H12FN3 |
| 分子量 | 265.29 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM. IC50 Value: 0.021 μM [1]Target: mGluRDipraglurant (ADX-48621) from Addex Therapeutics showed in vivo activity in different anxiety models in rat50 and is currently in phase II for the treatment of dyskinesia in Parkinson's disease. References:
[1]. The Synthesis and Use of Certain Pyridine Derivatives as Modulators of the G-protein Coupled Receptors mGlu5 and P2Y12 |
