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IPSU
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IPSU图片
CAS NO:1373765-19-5
包装与价格:
包装价格(元)
2 mg询价
5 mg询价
10 mg询价
25 mg询价
50 mg询价
100 mg询价
200 mg询价
1 mL*10 mM(in DMSO)询价

IPSU是可口服和脑渗透性的选择性OX2R拮抗剂,pKi值为7.85。

产品描述

IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.

体外活性

BBAC or the selective OX2R antagonist IPSU bind rapidly and reach equilibrium very quickly in binding and/or functional assays[1].

体内活性

IPSU?exhibits an acceptable absolute oral bioavailability and a brain/blood concentration ratio that indicated favorable brain penetration.?IPSU increases sleep when dosed during the mouse active phase (lights off);?IPSU induces sleep primarily by increasing NREM sleep.?IPSU shows a fast onset of action, with a clear increase in total sleep time during the first hour afterdosing.?The effect lasts 4-5 h, after which time the total sleep time per hour is the same as on vehicle day[2]

Cas No.

1373765-19-5

分子式

C23H27N5O2

分子量

405.502

储存和溶解度

DMSO:30 mg/mL (73.98 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
 
 
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