Leptomerine 是分离自Esenbeckia leiocarpaEngl. (Rutaceae) 茎中的生物碱。它抑制乙酰胆碱酯酶，IC50为 2.5 μM，具有抗胆碱能活性。它可用于研究阿尔茨海默症。

Leptomerine is an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae). Leptomerine shows as anticholinesterasic activity and can be used in Alzheimer Disease studies.

Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, Leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid Leptomerine showed the highest activity (IC50 = 2.5 mM), similar to that of the reference compound galanthamine (IC50 = 1.7 mM).

22048-97-1

C13H15NO

201.26

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years