ZL006 是一种 nNOS/PSD-95 相互作用抑制剂，能够抑制 NMDA 受体介导的 NO 合成。
产品描述
ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis.
体外活性
ZL006 growth inhibition of BCECs is not found at a low concentration of 0.001, 0.01, 0.1, 1, and 10 μg/mL. The cytotoxicity of T7-P-LPs/ZL006 is obviously enhanced at the concentration of 10 μg/mL. Cellular uptake of ZL006 loads P-LPs and T7-P-LPs after incubation for 0.5 h at the concentrations range from 100 μg/mL to 600 μg/mL in BCECs [1][2].
体内活性
T7-P-LPs/ZL006 displays a significant enhance in drug accumulation in the brain tissue due to its better brain targeting delivery compared with P-LPs/ZL006 and free ZL006. P-LPs/ZL006 and T7-P-LPs/ZL006 show a significant decrease in drug accumulation in the liver and kidney compared with free ZL006 [1].
Cas No.
1181226-02-7
分子式
C14H11Cl2NO4
分子量
328.15
储存和溶解度
DMSO:29 mg/mL (88.37 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
