Epiberberine chloride 是一种从黄连中得到的生物碱，是一种AChE和BChE抑制剂，和非竞争性的BACE1抑制剂。它具有抗氧化作用，能够清除 ONOO-，可用于研究阿尔滋海默症和糖尿病。

Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07, 6.03 and 8.55 μM).

Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease[1]. Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes (IC50: 52.8 μM). Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation [2]. Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner [3].

Body weight, food consumption, water intake, and urinary output of KK-Ay mice were reduced after being treated with Epiberberine (225 mg/kg, p.o. daily for 40 days).

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C20H18ClNO4

371.82

表小檗碱氯化物;Epiberberine (chloride);盐酸表小檗碱

DMSO:7.4 mg/mL (19.9 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years