7-Desmethyl-agomelatine is a major metabolite of Agomelatine. Agomelatine (S20098; BAN, rINN; Valdoxan, Melitor, Thymanax) is a potent
and specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06,
0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2,
respectively. It is a unique antidepressant and is developed for
treatment of major depressive disorder (MDD). It shows low affinities to
cloned human 5-HT2A and 5-HT1A. In the in vivo studies, agomelatine
causes increase of dopamine and noradrenaline levels via blocking the
inhibitory input of 5-HT2C.