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Neostigmine Bromide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Neostigmine Bromide图片
CAS NO:114-80-7
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)询价
100mg询价
500mg询价

溴化新斯的明是一种胆碱酯酶抑制剂，用于治疗重症肌无力。
Cas No.114-80-7
别名溴化新斯的明; Eustigmin bromide; Neoserine bromide
化学名[3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium;bromide
Canonical SMILESCN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C.[Br-]
分子式C12H19N2O2.Br
分子量303.2
溶解度≥ 15.16mg/mL in Water
储存条件Store at -20°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Neostigmine bromide is a reversible inhibitor of acetylcholinesterase.[1]

AChE (acetylcholinesterase) is a hydrolase that hydrolyzes the neurotransmitter acetylcholine at the neuromuscular junction and cholinergic synaspe. It terminates the signal transductions and plays a role in neuronal apoptosis.

Neostigmine bromide is a quaternary amine that blocked cholinesterase activity to extend and enhance the muscarinic and nicotinic effects of acetylcholine. It is implicated for the treatment of primary open-angle glaucoma, postoperative urinary retention, paralytic ileus, myasthenia gravis etc. It is also reported to be an adjuvant to local anaesthetics and opioids for post-surgical pain after gynaecological or abdominal surgery. [1]

Reference:
[1] El-Kosasy AM, Nebsen M, Abd El-Rahman MK, Salem MY, El-Bardicy MG.  Comparative study of 2-hydroxy propyl beta cyclodextrin and calixarene as ionophores in potentiometric ion-selective electrodes for neostigmine bromide.  Talanta. 2011 Aug 15;85(2):913-8. 

 
 
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