J147 是一种高效的、具有口服活性的、可透过血脑屏障神经保护剂，可增强认知能力。它抑制单胺氧化酶 B 和多巴胺转运体，EC50分别为 1.88 μM 和 0.649 μM。它有研究阿尔茨海默氏症的潜力。
产品描述
J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate initially developed for the treatment of neurodegenerative conditions associated with aging that impacts many pathways implicated in the pathogenesis of diabetic neuropathy.
Cas No.
1146963-51-0
分子式
C18H17F3N2O2
分子量
350.34
别名
J147
储存和溶解度
DMSO:35 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
