Prochlorperazine Maleate 是一种吩噻嗪类抗精神病药，主要用于治疗恶心、呕吐和眩晕。它比氯丙嗪更容易引起锥体外系疾病。

Prochlorperazine maleate is a phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS.

Prochlorperazine down-regulates cyclin E2 and reduces cell proliferation in MCF-7 cells that are resistant to tamoxifen. It has the potential to impact on estrogen receptor (ER) function and alter response to endocrine therapy[2].

Prochlorperazine is showed to be able to induce antinociception in mice. prochlorperazine-treated mice show a complete integrity of motor co-ordination on the rota-rod test, normal spontaneous motility, as well as exploratory behaviour as revealed by the hole-board test. The antinociceptive effect of prochlorperazine appears to be due to the antagonism of D2 receptors since the increase of the pain threshold induced by the investigated compound is prevented by pretreatment with the D2 agonist quinpirole[1].

Cells are treated 5 μM of prochlorperazine for 5 days and cell proliferation is measured by methylene blue staining or for 2 days and cyclin E2 mRNA levels are measured by qPCR.(Only for Reference)

84-02-6

C28H32ClN3O8S

606.09

Prochlorperazin;Stemetil;丙氯拉嗪;Prochlorperazine dimaleate salt;Capazine;Compazine

Ethanol:2 mg/mL (3.3 mM),warmed
DMSO:15.2 mg/mL (25 mM)
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years