(S)-(+)-Ibuprofen ((S)-Ibuprofen) 是布洛芬的 S(+)-对映异构体，是一种有效的 COX-1 和 COX-2 抑制剂，IC50 为 2.1 μM，分别为 1.6 μM。
| Cas No. | 51146-56-6 |
| 别名 | (S)-(+)-布洛芬; (S)-Ibuprofen |
| 化学名 | (2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid |
| Canonical SMILES | CC(C)CC1=CC=C(C=C1)C(C)C(=O)O |
| 分子式 | C13H18O2 |
| 分子量 | 206.28 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects[1][2]. References:
[1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14.
[2]. Xu HR, et al. The effect of CYP2C19 activity on pharmacokinetics of lansoprazole and its active metabolites in healthy subjects. Pharm Biol. 2010 Aug;48(8):947-52. |
