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Etodolac
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Etodolac图片
CAS NO:41340-25-4
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)询价
50mg询价
100mg询价
500mg询价

Etodolac (AY-24236) 是一种非甾体抗炎化合物，是一种非选择性的 COX 抑制剂 (IC50=53.5 nM)IC50 ！！！目标:IC50:53.5 nM (COX)。
Cas No.41340-25-4
别名依托度酸; AY-24236
化学名2-(1,8-diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid
Canonical SMILESCCC1=CC=CC2=C1NC3=C2CCOC3(CC)CC(=O)O
分子式C17H21NO3
分子量287.35
溶解度≥ 14.4mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Etodolac (Lodine) is a selective Cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 53.5 nM. Etodolac, a non-steroidal anti-inflammatory drug (NSAID), has been reported to treat osteoarthritis and rheumatoid arthritis.

Etodolac was able to abolish the cell size decrease and block caspase-3/7 activity in TNFα-induced isolated rabbit articular chondrocytes [1]. However, studies have shown that etodolac at 24h could induce cell death in human malignant rhabdoid tumor cells (FRTK-1) in a dose-dependent manner. Additionally, etodolac has shown to increase caspase-8, -9 and -3 activity 3 at 24 or 48 h in FRTK-1 [2].

References:
[1] Kumagai K1, Kubo M, Imai S, Toyoda F, Maeda T, Okumura N, Matsuura H, Matsusue Y.The COX-2 selective blocker etodolac inhibits TNFα-induced apoptosis in isolated rabbit articular chondrocytes. Int J Mol Sci. 2013 Sep 30;14(10):19705-15.
[2] Hakozaki M1, Hojo H, Kikuchi S, Abe M. Etodolac, a selective cyclooxygenase-2 inhibitor, induces apoptosis by activating caspases in human malignant rhabdoid tumor cells (FRTK-1). Oncol Rep. 2007 Jan;17(1):169-73.

 
 
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